**************************************************************************************************** * PROGRAM OVERVIEW **************************************************************************************************** * * PROGRAM: create_tableofcontents.sas * Created (mm/dd/yyyy): 02/09/2021 * *-------------------------------------------------------------------------------------------------- * PURPOSE: This macro createas a dataset with 1 row per table and figure that is used as the * report table of contents * * Program inputs: * * Program outputs: * -tableofcontents: dataset containing table of contents * * PARAMETERS: * * Programming Notes: * * *-------------------------------------------------------------------------------------------------- * CONTACT INFO: * Sentinel Coordinating Center * info@sentinelsystem.org * ***************************************************************************************************; %macro create_tableofcontents(); %put =====> MACRO CALLED: create_tableofcontents; /*********************************************************************************************/ /* Utility macro to add row to tableofcontents file */ /*********************************************************************************************/ %macro addtotoc(tabnum=, caption=, appendixtype=); data tableofcontents; set tableofcontents end=eof; output; if eof then do; tabnum = "&tabnum."; caption = "&caption."; appendixtype = "&appendixtype."; output; end; run; %mend; /*********************************************************************************************/ /* Initialize empty table and table number */ /*********************************************************************************************/ data tableofcontents; length tabnum $25 caption $500 appendixtype $30; call missing(tabnum, caption, appendixtype); run; %let number = 1; %let tablenum = 1; /*********************************************************************************************/ /* Build table of contents */ /*********************************************************************************************/ /*********************************************************************************************/ /* Glossary rows */ /*********************************************************************************************/ %addtotoc(tabnum=Glossary (CIDA), caption=List of Terms to Define Cohort Identification and Descriptive Analysis (CIDA) Found in this Report); %if %str("&reporttype") = %str("T2L2") | %str("&reporttype") = %str("T4L2") %then %do; %addtotoc(tabnum=Glossary (PSA), caption=List of Terms to Define Propensity Score Analysis (PSA) Found in this Report); %end; /*********************************************************************************************/ /* Baseline Table */ /*********************************************************************************************/ %if %eval(&numbaselinetablegrp.>0) %then %do; /*counter for determining table letter*/ %let tablecount = 1; /* counter for determining table number */ %let tablenum = 2; /*loop through each baseline table*/ %do b = 1 %to &numbaselinetablegrp.; %let analysisgrp = ; %let analysisgrp2 = ; %let baselinegroupnum = ; %let pregnancylabel = ; %let includenonpregnant = N; /*for L2 tables - need to reference PS/CS specific files to pull additional parameters*/ %let ratio = F; %let psfile = ; %let weightlabel = ; %let weightscheme = ; %let pstrim = ; %let percentiles=; %let ratiolabel = ; %let caliperlabel = ; %let truncationlabel = ; %let psestimategrp = ; %let unadjusted = ; data _null_; set baselinefile(where=(order=&b.)); if _n_ = 1 then do; call symputx('analysisgrp', analysisgrp); call symputx('runid', runid); call symputx('cohort', cohort); call symputx('unique_psestimate',unique_psestimate); %if %sysfunc(prxmatch(m/T4L1/i,&reporttype.)) > 0 %then %do; if cohort in ('preg', 'nopreg') then do; if upcase(includenonpregnant) = 'Y' then call symput('pregnancylabel', ' Pregnancy Cohort and Non-Pregnancy Cohort'); else call symput('pregnancylabel', ' Pregnancy Cohort'); end; call symputx('includenonpregnant', upcase(includenonpregnant)); %end; if missing(baselinegroupnum)=0 then call symputx('baselinegroupnum', baselinegroupnum); end; /*if baselinegroupnum is specified, a 2nd row will exist in the file*/ if _n_ = 2 then do; if missing(baselinegroupnum)=0 then do; call symputx('analysisgrp2',analysisgrp); end; end; run; %if %sysfunc(prxmatch(m/T2L2|T4L2/i,&reporttype.)) > 0 %then %do; data _null_; set pscs_masterinputs(where=(analysisgrp = "&analysisgrp." and covarnum=0)); call symputx('psfile', strip(file)); call symputx('psestimategrp', psestimategrp); call symput('unadjusted', 'Unadjusted '); /*for unadjusted table label*/ if file = 'psmatchfile' then do; call symputx('ratio',upcase(ratio)); if upcase(ratio)='F' then call symputx("ratiolabel",'Fixed Ratio 1:'||strip(put(ceiling, 8.))); if upcase(ratio)='V' then call symputx("ratiolabel",'Variable Ratio 1:'||strip(put(ceiling, 8.))); call symputx("caliperlabel", cat(', Caliper: ', caliper)); end; if file = 'stratificationfile' then do; call symputx('pstrim', pstrim); call symputx('percentiles', percentiles); if missing(strataweight) =0 then call symputx('weightscheme', strataweight); if upcase(strataweight)= 'ATE' or missing(strataweight) then call symputx("weightlabel","Average Treatment Effect (ATE)"); else if upcase(strataweight)= 'ATT' then call symputx("weightlabel","Average Treatment Effect in the Treated (ATT)"); end; if file = 'iptwfile' then do; if upcase(ipweight)= 'ATE' then call symputx("weightlabel","Average Treatment Effect (ATE)"); else if upcase(ipweight)= 'ATES' then call symputx("weightlabel","Average Treatment Effect, Stabilized (ATES)"); else if upcase(ipweight)= 'ATT' then call symputx("weightlabel","Average Treatment Effect in the Treated (ATT)"); call symputx('truncationlabel',strip(put(truncweight, best.))||'%'); end; run; %end; /*determine if only 1 baseline table and set &tablecount to 0. Will occur if all the following are true: - 1 monitoring period - DP stratification = N - max(order) in baselinefile = 1 - if reporttype = T2L2, T4L2- then analysis must be covariate stratification*/ %if %eval(&b.=1) & %eval(&look_start.) = %eval(&look_end.) & &stratifybydp. = N & %eval(&numbaselinetablegrp.=1) %then %do; %if %sysfunc(prxmatch(m/T2L2|T4L2/i,&reporttype.)) = 0 %then %do; %let tablecount = 0; %end; %else %do; %if &psfile. = covstratfile %then %let tablecount = 0; %end; %end; /*Assign labels*/ %let baselinelabel = ; %let grouplabel = &analysisgrp.; %let psestimatelabel = &psestimategrp.; %if %length(&baselinegroupnum.)>0 %then %do; %let grouplabel2 = &analysisgrp2.; %end; %isdata(dataset=labelfile); %if %eval(&nobs.>0) %then %do; data _null_; set labelfile(in=a where=(group="&analysisgrp" and runid = "&runid")) %if %length(&baselinegroupnum.)>0 %then %do; labelfile(in=b where=(group="&analysisgrp2" and runid = "&runid")) %end; %if %sysfunc(prxmatch(m/T2L2|T4L2/i,&reporttype.)) > 0 %then %do; labelfile(in=c where=(group="&psestimategrp" and runid = "&runid")) %end; ; if a then do; if labeltype = 'grouplabel' then call symputx('grouplabel',label); if labeltype = 'baselinelabel' then call symputx('baselinelabel',cat(', ',strip(label), ',')); end; %if %length(&baselinegroupnum.)>0 %then %do; if b then do; if labeltype = 'grouplabel' then call symputx('grouplabel2',label); end; %end; %if %sysfunc(prxmatch(m/T2L2|T4L2/i,&reporttype.)) > 0 & &psfile. ne covstratfile %then %do; if c then do; if labeltype = 'grouplabel' then call symputx('psestimatelabel',label); end; %end; run; %end; %let captionlabel = %bquote(&grouplabel.&pregnancylabel&baselinelabel.); %if %length(&baselinegroupnum.)>0 %then %do; %let captionlabel = %bquote(&grouplabel.&pregnancylabel and &grouplabel2.&pregnancylabel&baselinelabel.); %end; %if %sysfunc(prxmatch(m/T2L2|T4L2/i,&reporttype.)) >0 & &psfile. ne covstratfile %then %do; %let captionlabel = %bquote(&psestimatelabel.); %end; /*1 block of code for both aggregate and DP tables*/ %macro baselinetoc(table); %if %eval(&unique_psestimate.) = 1 %then %do; %tableletter(); %addtotoc(tabnum=Table 1&tableletter., caption=%quote(&unadjusted.Characteristics of &captionlabel. (&table.) in the &database. from &startdateformatted. to &&enddate&periodid.formatted.)); %end; /*For L2 tables - up to 2 additional adjusted tables*/ %if %sysfunc(prxmatch(m/T2L2|T4L2/i,&reporttype.)) > 0 %then %do; /*PS Match Adjusted*/ %if &psfile. = psmatchfile %then %do; %tableletter(); %addtotoc(tabnum=Table 1&tableletter., caption=%quote(Adjusted Characteristics of &grouplabel. (Propensity Score Matched, &table.), &ratiolabel.&caliperlabel., in the &database. from &startdateformatted. to &&enddate&periodid.formatted.)); %end; /*Unweighted - IPTW and PS Stratum*/ %if (&psfile. = iptwfile & %eval(&unique_psestimate.) = 1) | (&psfile. = stratificationfile & ("&weightscheme." = "ATE" | "&weightscheme." = "ATT") & %eval(&pstrim.>=0)) %then %do; %tableletter(); %addtotoc(tabnum=Table 1&tableletter., caption=%quote(Unweighted Characteristics of &grouplabel. (Unweighted, Trimmed, &table.) in the &database. from &startdateformatted. to &&enddate&periodid.formatted.)); %end; /*Weighted - IPTW, PS Stratum, PS Stratification*/ %if &psfile. = iptwfile | &psfile. = stratificationfile %then %do; %if &psfile. = iptwfile %then %let stratumtitle = (Inverse Probability of Treatment Weighted, Trimmed, &table.), Weight: &weightlabel., Truncation: &truncationlabel.; %else %if "&weightscheme." = "ATE" | "&weightscheme." = "ATT" %then %let stratumtitle = (Propensity Score Stratum Weighted, Trimmed, &table.), Percentiles: &percentiles., Weight: &weightlabel.; %else %let stratumtitle =(Propensity Score Stratified, &table.), Percentiles: &percentiles.; %tableletter(); %addtotoc(tabnum=Table 1&tableletter., caption=%quote(Weighted Characteristics of &grouplabel. &stratumtitle., in the &database. from &startdateformatted. to &&enddate&periodid.formatted.)); %end; %end; /*Additional L2 tables*/ %mend; /*loop through each periodid*/ %do periodid = %eval(&look_start.) %to %eval(&look_end.); /*Aggregated*/ %baselinetoc(Aggregated); /*Output seperate table for each Data Partner - loop through each DP*/ %if &stratifybydp. = Y %then %do; %do dps = 1 %to %eval(&num_dp.); %let maskedID = %scan(&masked_dplist,&dps); %baselinetoc(&maskedid.); %end; %end; /*DP stratification*/ %end; /*loop through each periodid*/ %end; /*loop through each row in baselinefile*/ %end; /*include baseline tables in toc*/ /*********************************************************************************************/ /* Covariate Profile Table */ /*********************************************************************************************/ %if &numprofilecovarstoinclude > 0 %then %do; /* reset counter to reset table letter */ %let tablecount = 1; %do periodid = %eval(&look_start.) %to %eval(&look_end.); proc sql noprint ; select 'order='||strip(put(order,8.))||' and runid='||quote(strip(runid))||' and group='||quote(strip(group))||' and cohort='||quote(strip(cohort)) into :whereexpr separated by '@' from (select order, runid, group, case when(cohort is missing) then 'all' else cohort end as cohort from baselinefile where not missing(profilecovarstoinclude)) order by order; quit; %do wherenum = 1 %to %sysfunc(countw(&whereexpr, @)); %let where = %scan(&whereexpr,&wherenum, @); data _temp_agg_order_profile; set aggregate_profile(where=(periodid=&periodid and &where)); grouplabel=''; if cohort = 'mi' then group2=scan(group,1,'_'); else group2=group; if cohort = 'switch' then switchlabel = ' '; call symputx('runid',runid); run; %let profileswitches = 0; %if &reporttype = T6 %then %do; proc sql noprint; select max(switchstep) into :profileswitches from _temp_agg_order_profile; quit; %end; %isdata(dataset=_temp_agg_order_profile); %if &nobs > 0 %then %do; %do s = 0 %to &profileswitches; %if &reporttype = T6 %then %do; data _temp_agg_profile; set _temp_agg_order_profile (where=(switchstep = &s)); run; /* Join treatment file onto profile table to obtain product group */ proc sql noprint undo_policy=none; create table _temp_agg_profile as select a.*, b.group as productswitchgroup from _temp_agg_profile a inner join infolder.&&&runid._treatmentpathways b on a.group = b.analysisgrp and a.switchstep = b.switchevalstep; quit; %end; %else %do; proc datasets lib=work nolist; change _temp_agg_order_profile = _temp_agg_profile; run; %end; /* Check for existence of label file and join to profile dataset. Set grouplabel to missing if no labelfile */ %isdata(dataset=labelfile); %if &nobs > 0 %then %do; proc sql noprint undo_policy=none; create table _temp_agg_profile as select a.group, a.runid, a.order, a.periodid, b.label as grouplabel %if %index(&where,%str(cohort="mi")) %then %do; ,c.label as grouplabel2, a.group2 %end; %if %index(&where,%str(cohort="switch")) %then %do; ,d.label as switchlabel, a.productswitchgroup %end; from _temp_agg_profile(drop=grouplabel %if &reporttype = T6 %then %do; switchlabel %end;) a left join labelfile(where=(lowcase(labeltype)='grouplabel')) b on a.group = b.group and a.runid = b.runid %if %index(&where,%str(cohort="mi")) %then %do; left join labelfile(where=(lowcase(labeltype)='grouplabel')) c on a.group2 = c.group and a.runid = c.runid %end; %if %index(&where,%str(cohort="switch")) %then %do; left join labelfile(where=(lowcase(labeltype)='grouplabel')) d on a.productswitchgroup = d.group and a.runid = d.runid %end; ; quit; %end; %else %do; data _temp_agg_profile; set _temp_agg_profile; grouplabel2=''; switchlabel=''; run; %end; data _null_; set _temp_agg_profile(keep=group grouplabel order %if %index(&where,%str(cohort="mi")) %then %do; group2 grouplabel2 %end; %if %index(&where,%str(cohort="switch")) %then %do; productswitchgroup switchlabel %end; ); if _n_ = 1; if not missing(grouplabel) then call symputx('grouplabel',grouplabel); else call symputx('grouplabel',group); %if %index(&where,%str(cohort="nopreg")) %then %do; if not missing(grouplabel) then call symputx('grouplabel',catx(' ',grouplabel,'Non-Pregnancy')); else call symputx('grouplabel',catx(' ',group,'Non-Pregnancy')); %end; %else %if %index(&where,%str(cohort="preg")) %then %do; if not missing(grouplabel) then call symputx('grouplabel',catx(' ',grouplabel,'Pregnancy')); else call symputx('grouplabel',catx(' ',group,'Pregnancy')); %end; %else %if %index(&where,%str(cohort="mi")) %then %do; if not missing(grouplabel) then do; if not missing(grouplabel2) then call symputx('grouplabel',grouplabel2); else call symputx('grouplabel',group2); end; else do; call symputx('grouplabel',group2); end; %end; %else %if &reporttype = T6 %then %do; %if &s = 0 %then %do; if not missing(grouplabel) then do; call symputx('grouplabel',grouplabel); end; else do; call symputx('grouplabel',group); end; %end; %else %if &s = 1 %then %do; if not missing(grouplabel) then do; call symputx('grouplabel',grouplabel); end; else do; call symputx('grouplabel',group); end; %end; %else %if &s = 2 %then %do; if not missing(grouplabel) then do; call symputx('grouplabel',grouplabel); end; else do; call symputx('grouplabel',group); end; %end; %end; run; %tableletter(); %if &numprofilecovarstoinclude = 1 and &reporttype ^= T6 %then %let tableletter =; %else %if &numprofilecovarstoinclude = 1 and &profileswitches = 0 and &reporttype = T6 %then %let tableletter =; %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%quote(Characteristic Profile of &grouplabel in the &database. from &startdateformatted. to &&enddate&periodid.formatted.)); %end; /* _temp_agg_order_profile */ %end; /* switch loop */ proc datasets library=work nowarn noprint; delete _temp_agg_profile _temp_agg_order_profile; quit; %end; /* where loop */ %end; /* periodid loop */ %let tablenum = %eval(&tablenum + 1); %end; /* &numprofilecovarstoinclude > 0 */ /*********************************************************************************************/ /* Effect estimate table */ /*********************************************************************************************/ %if &numl2comparisons > 0 %then %do; /*loop through each baseline table*/ %do c = 1 %to &numl2comparisons; /* reset counter to reset table letter */ %let tablecount = 1; data _null_; set l2comparisonfile(where=(order=&c.)); call symputx('analysisgrp', analysisgrp); call symputx('runid', runid); run; /* Merge in group labels if they exist */ %let grouplabel = &analysisgrp; %isdata(dataset=labelfile); %if %eval(&nobs>0) %then %do; data _null_; set labelfile(in=a where=(group="&analysisgrp" and runid = "&runid")) ; if labeltype = 'grouplabel' then call symputx('grouplabel',label); run; %end; /* Store covarnums to determine covar labels */ proc sql noprint; select distinct covarnum into :covarlist separated by ' ' from l2_effectestimates_&look_end. where analysisgrp="&analysisgrp."; quit; %if &covarlist = 0 %then %let tablecount = 0; /* loop covarnums and assign subgroup label */ %do covarcount = 1 %to %sysfunc(countw(&covarlist)); %let covarnum = %scan(&covarlist,&covarcount); %if &covarnum = 0 %then %do; %let titleend = %str(); %end; %else %if &covarnum = 9000 %then %do; %let titleend = %str(and Data Partner); %end; %else %do; %if &covarnum < 1000 %then %do; proc sql noprint; select distinct strip(studyname) into: subgrouplabel from infolder.&&&runid._covariatecodes where covarnum = &covarnum.; quit; %end; %if &covarnum = 1000 %then %let subgrouplabel = Sex; %else %if &covarnum = 1001 %then %let subgrouplabel = Age Group; %else %if &covarnum = 1002 %then %let subgrouplabel = Year; %else %if &covarnum = 1003 %then %let subgrouplabel = Monitoring Period; %else %if &covarnum = 1012 %then %let subgrouplabel = Race; %else %if &covarnum = 1013 %then %let subgrouplabel = Hispanic Origin; %else %if &covarnum = 1014 %then %let subgrouplabel = Delivery Status; %else %if &covarnum = 2000 %then %let subgrouplabel = Match Method; %else %if &covarnum = 2001 %then %let subgrouplabel = Birth Type; %let titleend = %str(and &subgrouplabel); %end; %tableletter(); %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%quote(Effect Estimates for &grouplabel. in the &database. from &startdateformatted. to &&enddate&look_end.formatted., by Analysis Type &titleend.)); %end; /* covarcount */ %let tablenum = %eval(&tablenum + 1); %end; /* numl2comparison do loop */ %end; /* numl2comparison */ /*********************************************************************************************/ /* Type 5 summary tables */ /*********************************************************************************************/ %if %str("&reporttype") = %str("T5") %then %do; /*****************************************************************************************/ /* Type 5 Tables T1-T13 */ /*****************************************************************************************/ /*Example order of tables: 2a: Categorical - overall 2b: Continuous - all 2c: Categorical - by age group 2d: Continuous - by age group */ %macro t5toc(cattableid=, disttableid=, cattitle=, disttitle=); /*if both categorical and continuous tables specified, then need to ascertain master order between both tables*/ %if %str("&cattableid.") ne %str("") & %str("&disttableid.") ne %str("") %then %do; /*Because a user can select different stratifications for each table need to ascertain a master order from tablefile regardless of whether includeinreport = Y*/ /*if user excludes includeinreport = N from file, order may not match SOC standard order of operations */ proc sort data=input.&tablefile.(keep=table tablesub where=(table in ("&cattableid","&disttableid"))) out=_temptablefile; by table; run; data _temptablefile; set _temptablefile; by table; length order 3; if first.table then order = 1; else order = order+1; retain order; run; proc sort data=_temptablefile nodupkey; by tablesub; run; proc sort data=tablefile(keep=table tablesub stratificationorder tabletitle) out=_temptablefile1; by tablesub; run; *create dataset that maps categorical and continuous tables; data _tempmap; merge _temptablefile _temptablefile1(rename=table=cattable rename=stratificationorder=catstratificationorder where=(cattable="&cattableid")) _temptablefile1(rename=table=disttable rename=stratificationorder=diststratificationorder where=(disttable="&disttableid")); by tablesub; if missing(catstratificationorder) & missing(diststratificationorder) then delete; run; proc sort data=_tempmap; by order ; run; %end; %else %do; data _tempmap; set tablefile(keep=table tablesub stratificationorder tabletitle where=(table in (%if %str("&cattableid.") ne %str("") %then %do; "&cattableid" %end; %if %str("&disttableid.") ne %str("") %then %do; "&disttableid" %end;))); run; %end; /*Loop through each tablesub, determine whether to output categorical and/or continuous table*/ %isdata(dataset=_tempmap); %let t5tableobs = &nobs.; %let tablecount=1; %do i = 1 %to %eval(&t5tableobs.); %let cattablestratorder = 0; %let disttablestratorder = 0; data _null_; set _tempmap; if _n_ = &i. then do; if tablesub = 'overall' and "&stratifybydp." = "Y" then call symputx('tabletitle', ', by Data Partner'); else call symputx('tabletitle', tabletitle); /*Both requested - determine whether to print both tables*/ %if %str("&cattableid.") ne %str("") & %str("&disttableid.") ne %str("") %then %do; if missing(cattable) | missing(disttable) then call symputx('numtables', 1); else call symputx('numtables', 2); if missing(cattable)=0 then call symputx('cattablestratorder', catstratificationorder); if missing(disttable)=0 then call symputx('disttablestratorder', diststratificationorder); %end; %else %do; call symputx('numtables', 1); /*determine which table*/ if table = "&cattableid" then call symputx('cattablestratorder', stratificationorder); if table = "&disttableid" then call symputx('disttablestratorder', stratificationorder); %end; end; run; /*reset table letter counter if only 1 table*/ %if %eval(&t5tableobs.=1) & %eval(&numtables.=1) %then %let tablecount=0; %if %eval(&cattablestratorder.>0) %then %do; %tableletter(); %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%bquote(&cattitle. for &reporttitle. in the &database. from &startdateformatted. to &enddateformatted.&tabletitle.)); %end; %if %eval(&disttablestratorder.>0) %then %do; %tableletter(); %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%bquote(&disttitle. for &reporttitle. in the &database. from &startdateformatted. to &enddateformatted.&tabletitle.)); %end; %end; /*Save the table of contents datasets for use during the Type 5 report output process*/ %isdata(dataset=t5_tempmap); %if %eval(&nobs.>0) %then %do; data t5_tempmap; set t5_tempmap _tempmap (in=a); %if %varexist(_tempmap,stratificationorder) = 1 %then %do; if a and stratificationorder ne . then do; %if %str("&cattableid.") ne %str("") %then %do; cattable="&cattableid"; catstratificationorder = stratificationorder; %end; %else %if %str("&disttableid.") ne %str("") %then %do; disttable="&disttableid"; diststratificationorder = stratificationorder; %end; end; %end; run; %end; %else %do; /*dummy t5_tempmap file*/ data t5_tempmap; set _tempmap; %if %varexist(_tempmap,stratificationorder) = 1 %then %do; if stratificationorder ne . then do; %if %str("&cattableid.") ne %str("") %then %do; length cattable $3; cattable="&cattableid"; catstratificationorder = stratificationorder; %end; %else %if %str("&disttableid.") ne %str("") %then %do; length disttable $3; disttable="&disttableid"; diststratificationorder = stratificationorder; %end; end; %end; run; %end; proc datasets nowarn noprint lib=work; delete _temp:; quit; %let tablenum = %eval(&tablenum+1); %mend; /*T1/T2 - Days Supplied per Dispensing*/ %if %sysfunc(prxmatch(m/T1\b|T2\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=%if %sysfunc(prxmatch(m/T1\b/i,&tablelist.)) > 0 %then %do; T1 %end;, disttableid=%if %sysfunc(prxmatch(m/T2\b/i,&tablelist.)) > 0 %then %do; T2 %end;, cattitle=Categorical Summary of Days Supplied per Dispensing, disttitle=Continuous Summary of Days Supplied per Dispensing); %end; /*T3/T4 - Cumulative episode duration*/ %if %sysfunc(prxmatch(m/T3\b|T4\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=%if %sysfunc(prxmatch(m/T3\b/i,&tablelist.)) > 0 %then %do; T3 %end;, disttableid=%if %sysfunc(prxmatch(m/T4\b/i,&tablelist.)) > 0 %then %do; T4 %end;, cattitle=Categorical Summary of Patients%str(%') Cumulative Exposure Duration, disttitle=Continuous Summary of Patients%str(%') Cumulative Exposure Duration); %end; /*T5/T6 - Episode duration - all episodes*/ %if %sysfunc(prxmatch(m/T5\b|T6\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=%if %sysfunc(prxmatch(m/T5\b/i,&tablelist.)) > 0 %then %do; T5 %end;, disttableid=%if %sysfunc(prxmatch(m/T6\b/i,&tablelist.)) > 0 %then %do; T6 %end;, cattitle=Categorical Summary of All Treatment Episodes, disttitle=Continuous Summary of All Treatment Episodes); %end; /*T7/T8 - Episode duration - first episode*/ %if %sysfunc(prxmatch(m/T7\b|T8\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=%if %sysfunc(prxmatch(m/T7\b/i,&tablelist.)) > 0 %then %do; T7 %end;, disttableid=%if %sysfunc(prxmatch(m/T8\b/i,&tablelist.)) > 0 %then %do; T8 %end;, cattitle=Categorical Summary of First Treatment Episodes, disttitle=Continuous Summary of First Treatment Episodes); %end; /*T9/T10 - Episode duration - second and subsequent episodes*/ %if %sysfunc(prxmatch(m/T9\b|T10\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=%if %sysfunc(prxmatch(m/T9\b/i,&tablelist.)) > 0 %then %do; T9 %end;, disttableid=%if %sysfunc(prxmatch(m/T10\b/i,&tablelist.)) > 0 %then %do; T10 %end;, cattitle=Categorical Summary of Second and Subsequent Treatment Episodes, disttitle=Continuous Summary of Second and Subsequent Treatment Episodes); %end; /*T11 - All episode gaps*/ %if %sysfunc(prxmatch(m/T11\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=, disttableid=T11, cattitle=, disttitle=Continuous Summary of All Treatment Episode Gaps); %end; /*T12 - First episode gap*/ %if %sysfunc(prxmatch(m/T12\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=, disttableid=T12, cattitle=, disttitle=Continuous Summary of First Treatment Episode Gaps); %end; /*T13 - Second and subequent episode gaps*/ %if %sysfunc(prxmatch(m/T13\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=, disttableid=T13, cattitle=, disttitle=Continuous Summary of Second and Subsequent Treatment Episode Gaps); %end; /*****************************************************************************************/ /* Type 5 censor tables (T14-T17) */ /*****************************************************************************************/ /*****************************************************************************************/ /* Type 5 Dose Tables T18-T22 */ /*****************************************************************************************/ %if %sysfunc(prxmatch(m/T18\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=T18, disttableid=, cattitle=Summary of Filled Daily Dose in Each Dispensing, disttitle=); %end; %if %sysfunc(prxmatch(m/T19\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=T19, disttableid=, cattitle=Summary of Average Filled Daily Dose in Each Treatment Episode, disttitle=); %end; %if %sysfunc(prxmatch(m/T20\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=T20, disttableid=, cattitle=Summary of Average Filled Daily Dose in Each Patient%str(%')s First Valid Episode, disttitle=); %end; %if %sysfunc(prxmatch(m/T21\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=T21, disttableid=, cattitle=Summary of Cumulative Filled Dose in All Treatment Episodes, disttitle=); %end; %if %sysfunc(prxmatch(m/T22\b/i,&tablelist.)) > 0 %then %do; %t5toc(cattableid=T22, disttableid=, cattitle=Summary of Cumulative Filled Dose in Each Patient%str(%')s First Treatment Episode, disttitle=); %end; /*Additional variables for ordering Type 5 table report output*/ data t5_tempmap; set t5_tempmap; length t5order 3; t5order=_n_; run; proc sort data = t5_tempmap; by table t5order; run; data t5_tempmap; set t5_tempmap; by table; length numtables tableorder 3; if first.table and last.table %if %varexist(t5_tempmap,cattable) = 1 & %varexist(t5_tempmap,disttable) = 1 %then %do; and (cattable = '' or disttable = '') %end; then numtables=1; else numtables=2; retain tableorder; if first.table then tableorder=0; tableorder+1; run; proc sort data = t5_tempmap; by t5order table; run; %end; /*type 5 tables*/ /*********************************************************************************************/ /* Code Distribution Tables */ /*********************************************************************************************/ %if &output_code_distribution. eq Y %then %do; /* This macros output a specific distribution type (EXP or HOI) entries in the table of content */ %macro codedistribution_type_toc(distindextype=); /* Compute group label to display in title */ %let grouplabel=; %isdata(dataset=labelfile); %if %eval(&nobs>0) %then %do; proc sql noprint; select label into :grouplabel trimmed from labelfile where lower(group)="&group." and runid = "&runid" and %if &distindextype. eq exp %then %do; lower(labeltype)="grouplabel"; %end; %else %do; lower(labeltype)="outcomelabel"; %end; quit; %end; %if %str("&grouplabel.") eq %str("") %then %let grouplabel = %trim(&group.); /* Full Code Distribution Table */ %tableletter(); %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%quote(Full Code Distribution of &grouplabel. in the &database. from &startdateformatted. to &enddateformatted.)); /* Total Code Counts Table */ %tableletter(); %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%quote(Total Code Counts of &grouplabel. in the &database. from &startdateformatted. to &enddateformatted.)); %mend codedistribution_type_toc; /* reset counter to reset table letter */ %let tablecount=1; proc sql noprint; select count(*) into :numgroupscodedist trimmed from GroupsDist; quit; %do loopcount = 1 %to &numgroupscodedist.; %let codedistexp = N; %let codedisthoi = N; data _null_; set GroupsDist; if &loopcount. = _N_; call symputx('runid', runid); call symputx('group', group); if index(upcase(codedist), "EXP") > 0 then call symputx('codedistexp', 'Y'); if index(upcase(codedist), "HOI") > 0 then call symputx('codedisthoi', 'Y'); run; %if &codedistexp. eq Y %then %do; * Defensive: make sure the requested data is available; %let obscount=0; proc sql noprint; select count(*) into :obscount from codedistdata where lower(group) = "&group." and runid = "&runid" and lower(distindextype) = "exp"; quit; %if %eval(&obscount. > 0) %then %codedistribution_type_toc(distindextype=exp); %end; %if &codedisthoi. eq Y %then %do; * Defensive: make sure the requested data is available; %let obscount=0; proc sql noprint; select count(*) into :obscount from codedistdata where lower(group) = "&group." and runid = "&runid" and lower(distindextype) = "hoi"; quit; %if %eval(&obscount. > 0) %then %codedistribution_type_toc(distindextype=hoi); %end; %end; *numgroupscodedist; %let tablenum = %eval(&tablenum + 1); %end; /*********************************************************************************************/ /* Attrition table */ /*********************************************************************************************/ %isdata(dataset=agg_patient_attrition); %let attrition_patient = &nobs; %isdata(dataset=agg_episode_attrition); %let attrition_episode = &nobs; /* reset counter to reset table letter */ %let tablecount=1; %if &attrition_patient > 0 or &attrition_episode > 0 %then %do; %if (&attrition_patient > 0 and &attrition_episode = 0) or (&attrition_patient = 0 and &attrition_episode > 0) %then %do; %let tablecount = 0; %end; %if &attrition_episode > 0 %then %do; %tableletter(); %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%quote(Summary of Episode Level Cohort Attrition in the &database. from &startdateformatted. to &enddateformatted.)); %end; %if &attrition_patient > 0 %then %do; %tableletter(); %addtotoc(tabnum=Table &tablenum.&tableletter., caption=%quote(Summary of Patient Level Cohort Attrition in the &database. from &startdateformatted. to &enddateformatted.)); %end; %let tablenum = %eval(&tablenum + 1); %end; /* attrition_groups file */ /*** END TABLES **/ /*********************************************************************************************/ /* Figures */ /*********************************************************************************************/ %isdata(dataset=figurefile); %if %eval(&nobs.>0) %then %do; %let figurenum = 1; /* Add +1 for additional figure types that are requested */ %let tablecount = 1; /***************************************************************************************/ /* L1 Figures */ /***************************************************************************************/ %if %sysfunc(prxmatch(m/T1|T2L1|T5|T6/i,&reporttype.)) > 0 %then %do; /*utility macro to loop through groups*/ %macro l1kmtoc(figure=, title =); %if %sysfunc(prxmatch(m/F1|F2|F3/i,&figurelist.)) > 0 %then %do; %let figure_dataset = figure123; %end; %else %do; %let figure_dataset = figure&figure.; %end; %isdata(dataset=&figure_dataset.); %if %eval(&nobs.>0) %then %do; /*number of distinct groups in figure to loop through determine whether to add letter to figure #*/ proc sql noprint; select distinct order into :fgrouporderlist separated by ' ' from &figure_dataset. order by order; quit; %if %sysfunc(countw(&fgrouporderlist.)) = 1 %then %let tablecount = 0; %else %let tablecount = 1; %do g = 1 %to %sysfunc(countw(&fgrouporderlist.)); %let order = %scan(&fgrouporderlist., &g.); %let grouplabel = ; %let switch2indicator = ; data _null_; set &figure_dataset.(where=(order = &order.)); if _n_ = 1 then do; call symputx('grouplabel', grouplabel); end; run; %tableletter(); %addtotoc(tabnum=Figure &figurenum.&tableletter., caption=%quote(&title. Among &grouplabel. in the &database. from &startdateformatted. to &enddateformatted.)); %end; /*loop through each figure*/ %let figurenum = %eval(&figurenum.+1); %end; /*figure dataset exists*/ %mend; /********************************************************************************************** T1: 1 figure: 1) F1: t1censor = Reasons for End of Observable Data by Group (1-CDF) - 1 figure per group /**********************************************************************************************/ %if &reporttype. = T1 %then %do; %l1kmtoc(figure=F1, title =Reasons for End of Observable Data); %end; /*T1*/ /********************************************************************************************** T2L1: 3 figures: 1) F1: t2followuptime = Kaplan-Meier Estimate of Event of Interest Not Occurring 2) F2: t2followuptime = Reasons for End of Follow-Up by Group (1-CDF) 3) F3: t2censor = Reasons for End of Observable Data by Group (1-CDF) /**********************************************************************************************/ %if &reporttype. = T2L1 %then %do; /*F1: 1 figure per report*/ %isdata(dataset=figuref1); %if %eval(&nobs.>0) %then %do; %addtotoc(tabnum=Figure &figurenum., caption=%quote(Kaplan-Meier Estimate of Event of Interest Not Occurring in the &database. from &startdateformatted. to &enddateformatted.)); %let figurenum = %eval(&figurenum.+1); %end; /*F2: 1 figure per group*/ %if %sysfunc(prxmatch(m/F2/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F2, title =Reasons for End of Follow-Up); %end; /*figuref2*/ /*F3: 1 figure per group*/ %if %sysfunc(prxmatch(m/F3/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F3, title =Reasons for End of Observable Data); %end; /*figuref3*/ %end; /*T2L1*/ /********************************************************************************************** T5: 5 figures: 1) F1: Patient Entry into Study by Month 2) F2: Number of Prescription Dispensings in Patients First Episodes by Month 3) F3: Total Days Supply in Patients First Episodes by Month 4) F4: t5censor = Reasons for End of First Treatment Episode by Group 5) F5: t5censor = End of First Treatment Episode due to [Censoring Reason] by Group /**********************************************************************************************/ %if &reporttype. = T5 %then %do; /* F1 */ %if %sysfunc(prxmatch(m/F1/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F1, title =Patient Entry into Study by Month); %end; /* F2 */ %if %sysfunc(prxmatch(m/F2/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F2, title =Number of Prescription Dispensings in Patients%str(%') First Episodes by Month Patient Entered into Study); %end; /* F3 */ %if %sysfunc(prxmatch(m/F3/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F3, title =Total Days Supply in Patients%str(%') First Episodes by Month Patient Entered into Study); %end; /*F4: 1 figure per group*/ %if %sysfunc(prxmatch(m/F4/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F4, title =Reasons for End of First Treatment Episode); %end; /*figuref4*/ /*F5: 1 figure per report*/ %if %sysfunc(prxmatch(m/F5/i,&figurelist.)) > 0 %then %do; data _null_; set figurefile(where=(figure="F5")); call symputx('censordisplay', censordisplay); run; %l1kmtoc(figure=F5, title =%quote(End of First Treatment Episode due to &&&censordisplay._label in the &database. from &startdateformatted. to &enddateformatted.)); %end; %end; /*T5*/ /********************************************************************************************** T6: 7 figures: 1) F1 (not yet implemented) 2) F2 (not yet implemented) 3) F3 (not yet implemented) 4) F4: t6plota = Kaplan-Meier Estimate of First Switch Not Occurring 5) F5: t6plotb = Kaplan-Meier Estimate of Second Switch Not Occurring 6) F6: t6plota = Reasons for Censoring at First Switch Evaluation by Analysisgrp 7) F7: t6plotb = Reasons for Censoring at Second Switch Evaluation by Analysisgrp /***********************************************************************************************/ %if &reporttype. = T6 %then %do; /*F4 - F7: 1 figure per group*/ %if %sysfunc(prxmatch(m/F4/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F4, title =Kaplan-Meier Estimate of First Switch Not Occurring); %end; /*figuref4*/ %if %sysfunc(prxmatch(m/F5/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F5, title =Kaplan-Meier Estimate of Second Switch Not Occurring); %end; /*figuref5*/ %if %sysfunc(prxmatch(m/F6/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F6, title =Reasons for Censoring at First Switch Evaluation); %end; /*figuref6*/ %if %sysfunc(prxmatch(m/F7/i,&figurelist.)) > 0 %then %do; %l1kmtoc(figure=F7, title =Reasons for Censoring at Second Switch Evaluation); %end; /*figuref7*/ %end; /*T6*/ %end; /*L1 figures*/ /***************************************************************************************/ /* L2 Figures */ /***************************************************************************************/ %if %sysfunc(prxmatch(m/T2L2|T4L2/i,&reporttype.)) > 0 %then %do; /*F1: PS distribution histograms*/ %if %sysfunc(prxmatch(m/F1/i,&figurelist.)) > 0 %then %do; proc sql noprint; select count(distinct AnalysisGrp) into: numPScomparisons from l2comparisonfile(where=(OutputPSDistribution="Y")); quit; %do loopcount = 1 %to &numl2comparisons.; data _NULL_; set l2comparisonfile(where=(order=&loopcount.)); call symputx('runid', runid); call symputx('analysisgrp', analysisgrp); call symputx('OutputPSDistribution', OutputPSDistribution); run; %if &OutputPSDistribution. = Y %then %do; %isdata(dataset=labelfile); %let grouplabel=&analysisgrp.; %if %eval(&nobs>0) %then %do; data _NULL_; set labelfile(where=(lowcase(labeltype)='grouplabel')); if group="&analysisgrp." and runid = "&runid"; call symputx('grouplabel', Label); run; %put &grouplabel.; %end; %let andafter=; proc sql noprint; select strip(file) into: psfile from pscs_masterinputs where analysisgrp = "&analysisgrp."; quit; %if &psfile. = psmatchfile | &psfile. = stratificationfile | &psfile. = iptwfile %then %do; data _null_; set pscs_masterinputs (where=(lowcase(analysisgrp)="&analysisgrp.")); call symputx("psestimategrp", lowcase(psestimategrp)); %if &psfile. = psmatchfile %then %do; if upcase(ratio) = "F" then do; call symput("andafter", " and After"); end; %end; %if &psfile = iptwfile %then %do; call symput("andafter", " and After"); %end; %else %if &psfile = stratificationfile %then %do; if upcase(strataweight) in ("ATE", "ATT") then do; call symput("andafter", " and After"); end; %end; run; %do j = %eval(&look_start) %to %eval(&look_end); %if &numPScomparisons.=1 and %eval(&look_end)=1 %then %do; %let tablecount = 0; %end; %tableletter(); %addtotoc(tabnum=Figure &figurenum.&tableletter., caption=%quote(Histograms Depicting Propensity Score Distributions Before&andafter Adjustment for &grouplabel. in the &database. from &startdateformatted. to &&enddate&j.formatted.)) %end; /* loop periods */ %end; /*psfile*/ %end; /* OutputPSDistribution */ %end; /* loop comparisons */ %let figurenum = %eval(&figurenum.+1); %end; /*Histograms*/ /*F2: Forest Plots*/ %if %sysfunc(prxmatch(m/F2/i,&figurelist.)) > 0 %then %do; %if %sysfunc(prxmatch(m/T2L2/i,&reporttype.)) > 0 %then %let ForestRatioTitle = Hazard Ratios (HR); %else %let ForestRatioTitle = Odds Ratios (OR); %let tableletter=a; %let tablecount = 1; %do j = %eval(&look_start) %to %eval(&look_end); %do plot = 1 %to 7; %let forest_title = ; data _null_; set forest_&j(where=(plotorder=&plot)); call symputx("forest_title",forest_title); run; %if %length(&forest_title) > 0 %then %do; %tableletter(); %addtotoc(tabnum=Figure &figurenum.&tableletter., caption=%quote(Forest Plot of &ForestRatioTitle and 95% Confidence Intervals (CI) for &forest_title in the &database. from &startdateformatted. to &&enddate&j.formatted.)) %end; /* Forest title exists */ %end; /* loop plots */ %end; /* loop periods */ %let figurenum = %eval(&figurenum.+1); %end; /*Forest plots */ /*F3-F5: KM Plots - Type 2 only*/ %if &reporttype. = T2L2 & %sysfunc(prxmatch(m/F3|F4|F5/i,&figurelist.)) > 0 %then %do; *reset tablecount; %let tablecount = 1; /*loop through each analysisgrp - dataset only exists if curve computed*/ %do loopcount = 1 %to &numl2comparisons.; data _null_; set l2comparisonfile(where=(order=&loopcount.)); call symputx('runid', runid); call symputx('analysisgrp', analysisgrp); run; proc sql noprint; select distinct strip(file) into: pscsfile trimmed from pscs_masterinputs where analysisgrp = "&analysisgrp." and runid = "&runid"; quit; %if &pscsfile. = psmatchfile | &pscsfile. = stratificationfile %then %do; /*assign labels*/ data _null_; set pscs_masterinputs(where=(analysisgrp="&analysisgrp." and covarnum = 0)); call symputx("psestimategrp", lowcase(psestimategrp)); run; data _null_; set infolder.&&&runid._psestimationfile(where=(lowcase(psestimategrp)="&psestimategrp.")); call symputx('GRP1', eoi); call symputx('GRP0', ref); run; %let outcomelabel = Event of Interest; %let eoilabel = &grp1.; %let reflabel = &grp0.; %isdata(dataset=labelfile); %if %eval(&nobs.>0) %then %do; data _null_; set labelfile(in=a where=(group="&analysisgrp" and runid = "&runid" and labeltype = "outcomelabel")) labelfile(in=b where=(group="&grp1." and runid = "&runid." and labeltype = "grouplabel")) labelfile(in=c where=(group="&grp0." and runid = "&runid." and labeltype = "grouplabel")); if a then call symputx('outcomelabel', label); if b then call symputx('eoilabel', label); if c then call symputx('reflabel', label); run; %end; /*loop through periodid*/ %do j = %eval(&look_start) %to %eval(&look_end); /*F3*/ %isdata(dataset=figureF3_analysis&loopcount._&j.); %if %eval(&nobs.>0) %then %do; %tableletter(); %addtotoc(tabnum=Figure &figurenum.&tableletter., caption=%quote(Unadjusted Kaplan-Meier Estimate of &outcomelabel. Not Occurring Among &eoilabel. and &reflabel. in the &database. from &startdateformatted. to &&enddate&j.formatted.)); %end; /*F4*/ %isdata(dataset=figureF4_analysis&loopcount._&j.); %if %eval(&nobs.>0) %then %do; %tableletter(); %addtotoc(tabnum=Figure &figurenum.&tableletter., caption=%quote(Conditional Kaplan-Meier Estimate of &outcomelabel. Not Occurring Among &eoilabel. and &reflabel. in the &database. from &startdateformatted. to &&enddate&j.formatted.)); %end; /*F5*/ %isdata(dataset=figureF5_analysis&loopcount._&j.); %if %eval(&nobs.>0) %then %do; %tableletter(); %addtotoc(tabnum=Figure &figurenum.&tableletter., caption=%quote(Unconditional Kaplan-Meier Estimate of &outcomelabel. Not Occurring Among &eoilabel. and &reflabel. in the &database. from &startdateformatted. to &&enddate&j.formatted.)); %end; %end; /*loop through periodid*/ %end; /*only PSmatch or stratification*/ %end; /*if there is only 1 figure, rewrite figure # - this method is used instead of determining apriori b/c of the numerous permutations of situations that can lead to 1 figure */ proc sql noprint; select count(caption) into: countkm from tableofcontents where index(caption, 'Kaplan-Meier Estimate')>0; quit; %if %eval(&countkm.)=1 %then %do; data tableofcontents; set tableofcontents; if index(caption, 'Kaplan-Meier Estimate')>0 then do; tabnum = "Figure &figurenum."; end; run; %end; %let figurenum = %eval(&figurenum.+1); %end; /*KM plots*/ %end; /*L2 figures*/ %end; /* Figure file */ /*****************/ /* Appendices */ /*****************/ /*Appendix A*/ %addtotoc(tabnum=Appendix A, caption=Dates of Available Data for Each Data Partner (DP) as of Request Distribution Date &datedistributed.); /* The remaining appendices are created in appendix_driver.sas */ /*********************/ /* Remove empty rows */ /*********************/ data tableofcontents; set tableofcontents; if missing(tabnum)=0; run; %put =====> END MACRO: create_tableofcontents ; %mend create_tableofcontents;